Description overdue on 09/19/2014
- Latin name: Dermovate
- ATC code: D07AB01
- Active substance: Clobetasol (Clobetasol)
- Manufacturer: GlaxoSmithKline Pharmaceuticals, Poland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Ointment Dermoveyt (Dermovate merhem) contains 50 mg to lobetazola - Active substance.
Additional ingredients:
- 500 mg - sorbitan sesquioleate;
- 5 g - propylene glycol;
- 100 g - white soft paraffin.
Cream Dermoveyt (Dermovate cream) containing 50 mg of clobetasol - Active substance.
Additional ingredients:
- 11 g - glyceryl monostearate;
- 1, 5 g - arlatselya 165;
- 8 g of 4 - cetostearyl alcohol;
- 1, 25 g - beeswax substitute 6621;
- 47 g of 5 - propylene glycol;
- 50 mg - sodium citrate;
- 75 mg - hlorokrezola;
- 50 mg - citric acid monohydrate;
- 100 g - purified water.
Product form
The drug comes in the form Dermoveyt cream or ointment for external use .
One pack contains 1 aluminum tube with 25 grams of ointment or cream.
Pharmacological action
The anti-inflammatory.
Pharmacodynamics and pharmacokinetics
The medicament Dermoveyt refers to the group glucocorticosteroids and is used for external (topical) application. Application of a cream or ointment prevents edge position of neutrophils in the bloodstream, lowers production and inflammation effusion of lymphokines Prevents macrophage migration It reduces the intensity of the processes granulating and infiltration Thereby exerting anti-inflammatory, anti-exudative, anti-allergic and antipruritic effects of local character.
The mean Cmax clobetasol observed in the plasma 13 hours after the first application of 30 g in the form of an ointment to healthy skin (or 8 hours after repeated applications) and is equal to 0, 63 ng / ml.
The mean Cmax clobetasol by repeated application of 30 g in the form of a cream after 10 hours, more than a measure of the substrate ointment.
After a single application of 25 g ointment 3 hours in patients suffering eczema and psoriasis average Cmax plasma drug equal respectively - 4.6 ng / ml and 2.3 ng / ml.
The metabolism of the active ingredient of the drug Dermoveyt is not fully understood.
Indications
- various forms of eczema;
- psoriasis;
- discoid shape lupus erythematosus;
- Lichen planus;
- Pathology of the skin, are resistant to treatment with the less active external glucocorticosteroid drugs.
In the form of ointments Dermoveyt recommended for skin diseases, which are accompanied by dryness, thickening and hyperkeratosis, as an ointment base allows you to retain moisture in the skin.
Dermoveyt in the form of a cream recommended for use in the opposite case, when pathological processes with severe inflammation accompanied weeping.
Contraindications
- Cancer of the skin;
- acne vulgaris;
- Hyde's nodular prurigo;
- genital and perianal itching;
- perioral dermatitis;
- common pustular and plaque psoriasis;
- period breastfeeding ;
- Children under 1 year;
- fungal, viral and bacterial diseases of the skin (including chickenpox, herpes simplex, actinomycosis, tuberculosis of the skin );
- hypersensitivity to the components of the drug ingredients Dermoveyt.
Side effects
The local application of the drug Dermoveyt very rarely observed increased sensitivity.
Among the local manifestations of hypersensitivity observed: rash, erythema, pruritus, Local burning sensation of the skin, hives contact dermatitis and allergic etiology that occur at the site of the drug and the symptoms are similar to those for which the therapy and prescribers.
If you experience symptoms of hypersensitivity therapy with Dermoveyta must stop.
From endocrine system very rarely observed symptoms Cushing That occur when a large amount of an ointment or cream, as well as applying a preparation to extensive areas of skin, and are the result of significant systemic absorption of the drug. These symptoms are most likely in patients of children's and infants, as well as the use, after application of the drug, sealed bandages. It is worth remembering that babies use diapers may act as an airtight bandage.
When using older patients doses not exceeding 50 g per week, inhibition of the function of the pituitary or adrenal glands is temporary in nature, with the return of normal values of the data, the cancellation after a short course of therapy with the use of local glucocorticoid funds .
Occasionally, when assigning Dermoveyta was noted dilation of superficial blood vessels of the circulatory system, in particular with vigorous rubbing of the drug in the folds of the skin or the use of occlusive dressings.
For the skin and subcutaneous tissue was observed infrequently local atrophy , and atrophic band . Very rarely manifested exacerbation of the main symptoms of the disease, changes in pigmentation, thinning of the skin, hypertrichosis and Development in the form of pustular psoriasis . These symptoms are also more likely to occur when rubbed the drug in the folds of the skin or the use of occlusive dressings.
Instructions for use (method and dosage)
Instructions on Dermoveyt recommends applying a cream or ointment to the affected skin with a thin layer once or twice a day, depending on the severity of the lesion.
Cream Dermoveyt (Dermovate cream) is more suitable for pathologies with severe inflammation and weeping Whereas to apply ointment Dermoveyt, instructions for use is recommended for diseases accompanied by dry skin.
Dermoveytom course of therapy is determined individually based on the diagnosed disease and its severity, but should not exceed 4 weeks without further assess the feasibility of its extension.
In the case of aggravation of previous treatment of skin diseases is possible reappointment of short courses of therapy Dermoveytom.
If necessary, with incomplete disappearance of the external manifestations of the disease, after treatment Dermoveytom, switching to the use of less aggressive external agents from the group glucocorticosteroids.
In severe cases, lesions of the skin, especially in the presence of hyperkeratosis, can enhance anti-inflammatory effect of ointments and creams Dermoveyt using a polyethylene film as a bandage overnight. Occlusive dressing is applied to the affected area for a greater positive effect, in the event of which further progress in the treatment can be maintained without the imposition of occlusive dressings.
Recommended maximum weekly dose of ointment or cream is 50 g per week.
Overdose
Due to the fact that the dosage forms of the drug Dermoveyt apply only locally, the likelihood of developing symptoms of acute overdose minimum.
When manifestations of chronic overdose, due to prolonged use of the drug or the use of high doses may develop Cushing's syndrome Which is an indication for dose reduction or withdrawal of Dermoveyta therapy using topical corticosteroids. Abolition of therapy should be under constant supervision of a doctor, because of the risk of possible development failure adrenal cortex.
Cooperation
In connection with the appointment Dermoveyta exclusively topical clinically significant interactions with other drugs have not been found.
Terms of sale
Prescription.
Storage conditions
Store at temperatures not above 30 ° C.
Shelf life
24 months.
Cautions
Therapy with drugs group glucocorticosteroids local action is preferably carried out for a long period of time, particularly in the appointment of the group of drugs for the treatment of patients early childhood, because of possible suppression of adrenocortical function.
The use of drugs in children Dermoveyt requires mandatory monitoring by the physician of the patient, at least once every 7 days.
As a result, long-term care glucocorticosteroids may appear atrophic changes of the skin, usually more pronounced on the face.
Optionally applying an ointment or cream for ever necessary to protect the mucosa from getting eye medicament, since it can lead to the development of glaucoma.
Treatment psoriasis with Dermoveyta may be accompanied by recurrence of the underlying disease, the development of generalized pustular form pathology, increasing tolerance to the drug, systemic and local toxic reactions that occur due to violations of the barrier function of the skin, and therefore, need constant monitoring of the patient.
When signs of adherence to the basic disease secondary infection appoint conduct appropriate antibacterial treatment.
If any symptoms suggestive of generalization of infection Should cancel the therapy and prescribe adequate treatment with antibacterial drugs.
Keep in mind that when using occlusive dressings are moist warm conditions that promote bacterial infection In this connection it is necessary to thoroughly clean the affected areas of skin before applying another dressing.
Breeding drug Dermoveyt in the form of a cream is not recommended.
Analogs
Afloderm
Ftorokort
Lorinden
Lokoid
Analogs Dermoveyt cream or ointment may be administered during the transition to a less aggressive therapy, or due to any reason, in which the drug is not suitable for treatment of a particular patient.
You may be offered the following analogues Dermoveyta topical:
- Afloderm;
- Lokoid;
- Latikort;
- Triakort;
- Ftorokort etc.
Synonyms
- Pauerkort;
- Kloveyt.
Babies
Due to the possible suppression of adrenocortical function Dermoveyta not recommended in children or in large doses over a long period of time. With the passage of the children treat using local glucocorticoids necessary to carry out a comprehensive examination of the child at least once a week.
During pregnancy and lactation
The ointment and cream during Dermoveyt pregnancy may appoint a doctor. In any case, at this time it is not necessary to use local corticosteroids for a long time or at high doses.
During Lactation Dermoveyta safe use has not been established.
Reviews Dermoveyte
Reviews Dermoveyt ointment used to treat various skin diseases, including psoriasis, indicate a high efficacy, rapid relief and subsequently the complete disappearance of the external manifestations. Cream Dermoveyt also receives positive feedback.
In the user forums are mentions that when recurrence of psoriasis or eczema Previously Dermoveyt effective means, the reuse did not have the same strength the therapeutic action.
It should be noted that the frequent use of a cream or ointment, especially in large quantities, can be produced by the body's resistance to this drug. In this regard, the use of the drug is recommended only if indicated in minimally effective doses, particularly for the treatment of pediatric patients.
Price Dermoveyta where to buy
Cream Dermoveyt , Depending on the region, can be bought in pharmacies Russia at a price of 300 to 500 rubles.
Cost ointment Dermoveyt It varies approximately in the same range.
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