Ortofen

Description overdue on 27.10.2012

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Non-steroidal, anti-inflammatory drug . Active ingredient -   diclofenac . The drug Ortofen has antipyretic, analgesic and anti-inflammatory effects. The main component of the medicament is a derivative of phenylacetic acid. The main mechanism of action is aimed at non-selective inhibition of cyclooxygenase-1, 2, reducing the concentration of prostaglandins in inflammatory foci, infringement of metabolism arachidonic acid . The drug has an additional antiplatelet activity. Ortofen available in tablet form and as a solution, drops, suppositories, a gel and ointment.

Indications:

Ortofen prescribed for the treatment of diseases of the musculoskeletal system   degenerative and inflammatory genesis: Personeydzha disease-Turner   (neuralgic amyotrophy), ankylosing spondylitis (ankylosing spondylitis), chronic juvenile arthritis, rheumatism, Reiter's disease arthritis . psoriatic arthritis , Rheumatoid arthritis, osteoarthritis. The drug is effective for the relief of pain after surgery, injury, in cancer,   neuralgia , Sciatica, bursitis, myalgia, sciatica, arthralgia, toothache, migraine headaches, tendinitis , Ossalgia, lumbago. The drug is used for adnexitis, inflammatory diseases of the pelvic organs, with   algodismenoree , Otitis media, pharyngitis, tonsillitis and other diseases of the upper respiratory tract. The drug is prescribed for the relief of febrile syndrome that accompanies many infectious and for "common cold" diseases.

Contraindications:

Ortofen does not apply to "Aspirin" asthma , Intolerance of diclofenac, in a variety of disorders of blood clotting, in violation of hematopoiesis, with "Aspirin" triad   (recurrent nasal polyposis, paranasal sinuses combined with bronchial asthma and intolerance acetylsalicylic acid , Medicines pirazolonovogo series), when carrying a pregnancy, erosive and ulcerative lesions in the digestive tract, while Hemophilia , Breastfeeding, anemia, leukopenia, tendency to bleeding, prolongation of bleeding time, children up to the age of 6. Suppositories Ortofen not prescribed for inflammatory and traumatic lesions of the anus, rectum, when rectal bleeding , Hemorrhoids. When edema, alcoholism, kidney and liver failure, hypertension, erosive and ulcerative lesions of the digestive system in the form of decompensated chronic heart failure, anemia, asthma, diabetes In the postoperative period, induced acute hepatic porphyria and elderly patients Ortofen used with caution.

Side effect:

Gastrointestinal tract:   peptic ulcers, flatulence, constipation, dyspepsia, diarrhea syndrome, cramps, abdominal pain, increased liver enzymes, gastrointestinal bleeding, perforations , Dry mouth, thrush , The defeat of the esophagus, blood in the stool, melena, jaundice, hepatorenal syndrome , Hepatitis, cirrhosis, gepatonekroz, colitis, pancreatitis, perversion of taste perception. Nervous system:   anxiety, headache, weakness in the whole body, double vision, depression, drowsiness, sleep disturbances, seizures, aseptic meningitis . Senses: scotoma Possibly irreversible decline in auditory perception, blurred vision, taste disturbances. Skin:   itching, rash, eczema . hives , Alopecia, Lyell's syndrome, Stevens-Johnson syndrome , Chronic dermatitis, photosensitivity. Urogenital:   proteinuria, nephrotic syndrome , Fluid retention, azotemia, papillary necrosis, acute renal failure, interstitial nephritis , Oliguria. Bodies of blood:   rarely observed anemia, eosinophilia, leukopenia, thrombocytopenic purpura, agranulocytosis. Respiratory system:   laryngeal edema, cough, bronchoconstriction. Cardiovascular system: congestive heart failure, increased blood pressure. Allergic responses:   swelling of the tongue and lips, anaphylactic shock, anaphylactoid reactions.

Overdose:

Manifested myoclonic seizures , Epigastric pain, disorders of the liver and kidney, bleeding, decreased consciousness, hyperventilation pulmonary system, headaches and dizziness. Requires gastric lavage, the appointment of an emergency enterosorbents Holding posindromnoy therapy. Forced diuresis   and hemodialysis has not proven to be effective, do not apply.

Mode of application:

Ortofen not chew, taken after meals, inside .  The dosage for adults is 25-50 mg 2-3 times a day .  Amount of the drug gradually decreases at a desired therapeutic result and then move on to receive a maintenance dose of 50 mg / day .  In the treatment of rheumatoid arthritis, juvenile daily amount of medication may be increased to 3 mg / kg .  Retard form prescribed medication 1 time a day, 100 mg .  Injection drug Ortofen carried out intravenously, the daily amount of the drug - 150 mg .  Before the infusion of 1 mg of diclofenac (corresponds to 75 mg) was diluted in a sodium chloride solution, dextrose .  Infusion was carried out for 30-180 minutes, depending on the severity of pain .  "Shock" dose of medication administered for the relief of post-operative pain: for 15-60 minutes 25-50 mg .  Acceptable single intramuscular injection of a medicament for the relief of exacerbations of chronic diseases later move on to receive oral forms .  When migraine attacks should enter 1 suppository 100 mg rectally .  Reintroducing conducted as necessary in the same doses .

Special instructions:

Ortofen can take half an hour before eating to achieve faster therapeutic effect. In other cases, medication is recommended to take before, during, or after a meal. Tablet dosage forms are chewed, a necessary amount of liquid is drunk. An important role in maintaining the renal blood flow   take prostaglandins, which requires special treatment from the doctor to the patients with abnormal renal and cardiac systems, as well as makers diuretic drugs , With reduced blood volume. Prolonged therapy ortofenom requires periodic monitoring of liver function, state Peripheral Blood It is recommended to carry out regular fecal occult blood. Ortofen affects during certain motor and mental reactions, so it is advisable to refrain from driving motor vehicles and complex contracts for the period of treatment with diclofenac.

Drug Interactions:

Ortofen able to raise the level cyclosporine , Digoxin, lithium Methotrexate in blood. The drug reduces the severity of the action of diuretics, increases the risk of bleeding when receiving alteplase, urokinase, streptokinase, antiplatelet and anticoagulant agents. There is decrease in the effectiveness of antihypertensive drugs and sleeping pills. Ortofen increases nephrotoxicity   cyclosporine, methotrexate increases the toxic effect increases the severity of side effects glucocorticosteroids   and other medicines NSAIDs group. Do not appoint simultaneously with paracetamol. The drug reduces the effectiveness of hypoglycemic agents . Valproic acid, tsefotetan, cefamandole, plicamycin, ceftazidime increase the likelihood of gipoprotrombinemii . St. John's wort preparations, corticotropin, ethanol, colchicine significantly increase the risk of gastrointestinal bleeding . Drugs that the mechanism of action cause blocking tubular secretion, capable of increasing the level of the basic substance in the blood, which increases the toxicity and efficacy Ortofen.