Description overdue on 04/07/2014
- Latin name: Combilipen
- ATC code: A11BA
- Active substance: Pyridoxine, thiamine, cyanocobalamin
- Manufacturer: Pharmstandard-UfaVITA (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Combilipen
- Contraindications
- Side effects
- Instructions for use Combilipen (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
INN: + Cyanocobalamin Pyridoxine Thiamine + + [lidocaine].
The composition of 1 ml of this solution Combilipen comprises the following active ingredients: thiamine hydrochloride - 50 mg, pyridoxine hydrochloride - 50 mg, cyanocobalamin - 500 mg, Lidocaine hydrochloride - 10 mg. As adjuvants: benzyl alcohol . sodium hydroxide . potassium ferrocyanide . sodium tripolyphosphate . Water for Injection .
The composition 1 tablet contains: pyridoxine hydrochloride - 100 mg benfotiamine - 100 mg cyanocobalamin - 2 mg. As auxiliary substances: carmellose sodium . microcrystalline cellulose . povidone K30 . calcium stearate . talc . polysorbate . saccharose .
Product form
The drug is released into a solution for injection, and tablets. The medicine is contained in solution in 2 ml ampoule, is included in the package 5, 10 and 30 vials. Tubbs Combilipen tablets are round, white film-coated, biconvex. Realized in blister 15, 30, 45 or 60 pieces in a cardboard box.
Pharmacological action
The drug is a multivitamin complex, which includes several components.
Thiamine gidrohlogid (vitamin B1) provides power nerve cell body glucose. The lack of glucose leads to deformation and the subsequent increase in the nerve cells, which ultimately triggers the violation of their direct functions.
Pyridoxine hydrochloride (vitamin B6) is directly involved in the metabolic processes of CNS. It provides a normalization of nerve impulses, excitation and inhibition, and also participates in the synthesis of catecholamines (epinephrine, norepinephrine) transport and sphingosine (a component of the nervous sheath).
Cyanocobalamine (B12) involved in the production of choline - the main substrate for the synthesis of acetylcholine (acetylcholine is a neurotransmitter that participates in nervous impulses), hematopoiesis (promotes maturation of red blood cells and provides them with resistance to hemolysis). Cyanocobalamin also involved in the synthesis of nucleic acid . folic acid . myelin . It enhances the ability of the organism to regenerate tissues.
Pharmacodynamics and pharmacokinetics
Information about the pharmacokinetics and pharmacodynamics not provided.
Indications Combilipen
Indications for use of the drug - a number of neurological diseases:
- prosopalgia ;
- inflammation of the facial nerve ;
- polyneuropathy Having different origins of Origin: (diabetic, alcoholic polyneuropathy);
- pain in patients suffering from diseases of the spine ( intercostal neuralgia . lumbar and cervical syndrome . cervicobrachial syndrome . radicular syndrome . pathological changes in the spine ).
Price and feedback on the effect of the drug in the treatment of these diseases demonstrate its high performance when used in combination therapy.
Contraindications
There are contraindications for the use of the drug in the following cases:
- intolerance of components of the drug;
- heart failure;
- pregnancy and breastfeeding.
Side effects
Taking vitamins, the patient may note the following side effects:
- variety allergic reactions (itchy skin, hives, anaphylactic shock, edema);
- tachycardia ;
- acne ;
- hyperhidrosis .
Instructions for use Combilipen (method and dosage)
When using a solution of the drug injections are conducted intramuscularly .
If symptoms pronounced, injections are carried out for 5-7 days to 2 ml daily, followed by the introduction of Combilipen continues to 2-3 times a week for another two weeks.
In mild illness injection is carried out 2-3 times a week for no more than 10 days. Treatment solution Combilipen held not more than two weeks, the dosage is adjusted physician.
Instructions for use tablets Combilipen Tubbs follows: take the drug you need after a meal, drink a small amount of water, do not chew. Adult patients taking 1-3 tablets daily. The course of treatment prescribed specialist. Taking high doses of the drug can not be longer than four weeks.
Overdose
In case of overdose the patient can worsen the symptoms of side effects of medications. Perhaps the development of nausea . vomiting . dizziness . allergic reactions . tachycardia .
If an overdose, the patient should wash the stomach, give him pills Activated Carbon Appoint symptomatic treatment.
Cooperation
If Combilipen injections or taking the drug orally combined with levodopa treatment, decreases the impact on the body vitamin B6 .
Impossible drug injections with those substances which have a redox effect because they are incompatible with Vitamin B1 . It mercuric chloride . carbonate . iodide . acetate . tannic acid . Furthermore, the reception can not be combined with thiamine pentobarbital sodium . riboflavin . metabisulphite . benzilpenippllinom . Dextrose . Thiamine is rapidly destroyed by contact with copper. Also inactivation of thiamine, when the pH is greater than 3.
Cyanocobalamin not combined with heavy metals.
Terms of sale
The drug in pharmacies on prescription only.
Storage conditions
Store the solution preparation should be at a temperature of not higher than 8 degrees Celsius. The drug in the tablets should be stored at a temperature not higher than 25 degrees Celsius. Protect medicine from children.
Shelf life
Combilipen stored for 2 years.
Cautions
In the period of treatment should not be used simultaneously polyvitamins In structure of which there are B vitamins
Analogs
Vitasharm
Pikovit prebiotic
Pikovit Omega 3
Pikovit Forte
Pikovit
Vetoron children
Vetoron
Vetoron E
Undevit
Vitrum Lift-Q10 Skin
Pentovit
Vitrum Performance
In pharmacies sold Combilipen analogs, which include those similar to the active ingredients are present. Multivitamin preparations, which is composed of vitamins, there are many. Price analogs varies widely. When selecting analogue to consider what Combilipen, and which vitamins are included in its composition.
Is it better or Milgamma Combilipen?
Milgamma and Combilipen are analogous, they are made from different manufacturers. The impact on the human body both drugs have similar. However, the cost in pharmacies Milgamma higher.
Babies
As part of the drug is present benzyl alcohol, so to treat children Combilipen not apply.
With alcohol
If a person simultaneously with the treatment of drug taking alcohol dramatically reduces the absorption of thiamine. Therefore, discussing the compatibility with alcohol, it should be noted that taking alcohol during treatment is highly undesirable.
During pregnancy and lactation
The drug does not apply during the period pregnancy and breast-feeding .
Reviews
Reviews on Combilipen mostly positive. Patients mark its beneficial effect in the treatment of various complex neurological diseases . Leaving reviews injections and reviews Combilipen Tubbs, people celebrate it affordable price.
Due to the presence lidocaine as part injections are less painful than the introduction of analogues containing B vitamins Doctors about tablets and solution of this drug suggests that it has a pronounced positive effect in the treatment of osteochondrosis . As side reactions mentioned review the appearance of a small skin pruritus and urticaria.
Price, where to buy
Price Combilipen ampoules average about 200 rubles. (2 ml ampoule, 10 pieces). Price ampoules in a package of 5 pieces. an average of 120 rubles. Some networks pharmacies price Combilipen injections may be lower.
Medicine in the form of tablets is realized in average 180-190 rub. (price tablets Combilipen Tubbs to 30 pc. in a package). The drug tablets (package of 60 pcs.) Can be bought at the price of 300 rubles.
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