- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Tsitovir 3
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Tsitovir syrup for children
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One milliliter of syrup contains:
- as active ingredients - sodium salt of α-glutamyl-tryptophan - 1 ml bendazol - 1 25mkg, Ascorbic acid - 12 mg;
- as auxiliaries - saccharose Water.
Product form
Available in bottles of 50 ml with a spoon dosing. One such bottle in a carton box.
Pharmacological action
The drug has indirect antivirus (active against pathogens Flu A and B and other viruses that cause acute respiratory infections ) And anti-inflammatory .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Alpha-glutamyl-tryptophan (thymogen) increases immunomodulatory effects bendazol, enhancing T-cell immunity.
Ascorbic acid (vitamin C) It enhances membrane permeability of the capillaries, reducing the production of prostaglandins and other proteins of the inflammatory response, thereby showing anti-inflammatory . Ascorbic acid - a powerful antioxidant that reacts with free oxygen radicals, protecting cells from damage and improves the body's resistance to infections.
Bendazol initiates the synthesis interferons (inhibit the replication of viruses and intracellular parasites) in the body, exhibits immunostimulatory Associated with a change in the proportion of the content of cGMP and cAMP in the cells of the immune system (increases the amount of cGMP), this leads to an increase in the number of T and B lymphocytes Which in turn increases the effectiveness of the immune response of the whole organism.
Pharmacokinetics
Tsitovir syrup almost completely absorbed in the digestive tract. Bendazol Bioavailability is 80% alpha-glutamyl-tryptophan - 15%, ascorbic acid - less than 70%. Ascorbic acid is absorbed mainly in the middle sections of the intestine. The maximum concentration reached in 4-5 hours after administration. Ascorbic acid readily penetrates into all tissues and cells of the body, as well as the placenta.
In diseases of the stomach and intestines ( peptic ulcer . ascariasis . giardiasis and other diseases), increased content in the diet of fruits and vegetables, alkaline water binding and penetration of ascorbic acid into the body deteriorates. Ascorbic acid is metabolized primarily in the liver.
The decay products of ascorbic acid and bendazol the kidneys. Period of half-life of about 3 hours.
Alpha-glutamyl-tryptophan It disintegrates into individual amino acids, which are used to construct the cells of protein molecules.
Indications
Diseases: - SARS
- Flu
Given that Tsitovir 3 antiviral drug, it is used as a means of treatment and prevention of influenza and acute viral respiratory diseases .
Contraindications
Tsitrovir-3 is prohibited to use in the presence of:
- hypersensitivity to the drug and its components;
- diseases characterized by a decrease in muscle tone, convulsive state;
- severe Heart Failure ;
- atopic form asthma ;
- low blood pressure ;
- tendency to form blood clots;
- thrombophlebitis ;
- severe renal failure ;
- gastric ulcer and 12 duodenal ulcer Complicated by bleeding;
- Diabetes ;
- aged up to one year;
- pregnancy.
During breast-feeding, and either simultaneously pursued anticoagulation apply Tsitovir-3 under the close supervision and control of the doctor.
Side effects
Usually the drug is well tolerated, but in rare cases may experience the following side effects:
- by gastrointestinal tract - Heartburn, nausea;
- by genitourinary system : damage to kidney nephrons . crystalluria , Formation of stones in the kidneys and the bladder;
- allergic reactions : Redness, itching, rash, hives . angioedema ; rarely - anaphylactic shock ;
- by Endocrine : Damage pancreas ( glycosuria . hyperglycemia ) And impaired glycogen synthesis until the appearance of diabetes mellitus;
- by Cardiovascular : tachycardia , Prolonged use can cause a change in normal ECG as reduced value cardiac output . hypotension , Myocardial degeneration;
- by hematopoietic system : Increase in Platelet . neutrophil and / or prothrombin blood, reduction of erythrocyte in blood;
- from the central Nervous System : Irritability, headache, insomnia, dizziness;
- by respiratory system : Cough, shortness of breath;
- general reactions: fever . sweating . flushing of the face , The metabolism of zinc and copper.
Instructions for use Tsitovir 3
Child age implies that the syrup is more convenient to use than tablets or capsules. Instructions on Tsitovir-3 recommends taking syrup for children and adults for 30 minutes before eating.
Receiving Modes Tsitovir-3:
- 2 ml three times a day for children of up to 3 years for four days;
- 4 ml three times a day for children from 3 to 6 years for four days;
- 8 ml three times a day for children 6 to 10 years, for four days;
- 12 ml three times a day for children older than 10 years, for four days.
In order to prevent possible to repeat the course in 3-4 weeks.
Overdose
In case of overdose may cause the following symptoms: short hypotension . Sweating . dizziness . nausea . fever , headache.
These manifestations are treated symptomatically, but be sure to consult your doctor to decide on whether to continue taking the drug.
Cooperation
Features of interaction timogena with other drugs have been identified.
In a joint reception Ascorbic acid some antibiotics ( tetracycline and benzylpenicillin ) Concentration in the blood tends to increase. Vitamin C also improves the digestibility of substances containing iron, and also reduces the effect of heparin and other anticoagulants.
Aspirin Some contraceptives and fresh juices reduce the absorption of ascorbic acid. Aspirin reduces absorption of vitamin C by 30%, which in turn increases the probability of crystalluria during therapy salicylates and sulfonamides, increases half-life of the kidneys of some acids and drugs having an alkaline pH, decreases the blood levels of certain contraceptive reduces therapeutic effect of antipsychotics ( derived from phenothiazine), and slows down amphetamine and some antidepressants.
Barbiturates contribute to a more rapid removal of ascorbic acid in urine.
Bendazol at a joint reception with beta-blockers prevents an increase in total peripheral vascular resistance, with a joint reception with diuretics and antihypertensive agents enhances the hypotensive effect of the latter.
Phentolamine bendazol enhances the hypotensive effect.
Terms of sale
In Russia and Ukraine Tsitovir-3 it is sold only by prescription.
Storage conditions
- Keep out of the reach of children.
- Store in a dry, dark place.
- Store at temperatures up to 25 ° C.
Shelf life
Shelf life - 3 years (printed on).
Cautions
When multiple rates necessary to control blood glucose levels.
Analogs Tsitovira 3
Match code ATC 4th level: Some analogues Tsitovira-3 with an indication of the form of release: Alokin alpha (liofolozat for injection) Anaferon (pills), Arbivir-Health (tablets, capsules) Arbidol (capsules) Glutoxim (injection) Immunal (drops) Kagocel (pills), Lavomax (pills), Lynch (capsules) Orvirem (syrup) Timalin (liofolozat for injection) Ehinatsin Madaus (solution for internal use, lozenges). Summing up, we can say that the price is less than or close analogues to the price of Tsitovira-3.
The most frequently raised questions among patients on the comparative effectiveness of analogues.
Is it better or Orvirem Tsitovir?
There are different mechanisms of action of drugs. In Tsitovira-3 mediated immunostimulatory systemic action and Orvirem directly blocks the replication of viruses in cells. Among patients can hear frequent complaints about the appearance of allergies to Orviremu children.
Is it better or Kagocel Tsitovir?
A similar mechanism of action and indications of drugs. Hence, about the same feedback from the people using drugs. Therefore, the selection is better to do, based on the recommendation of doctors and feasibility.
What better Tsitovir or Anaferon?
Though Anaferon and is close Tsitoviru-3 claimed have effects, its mechanism of action, like that of most homeopathic drugs has not been studied and proven in independent studies. Among the patients and doctors are constantly waging a fierce debate about its usefulness.
Tsitovir syrup for children
This drug is contraindicated for use in children under one year.
When pregnancy
When pregnancy is welcome Tsitovira 3 contraindicated.
Reviews Tsitovir 3
Numerous reviews of syrup for children Tsitovir-3 divided roughly as follows: 30% - negative, 70% - positive or close to neutral. Most patients use the drug note the absence of " drug "Flavor and a more convenient form release (syrup) and compared with the analogues (capsules, tablets, injections).
Reviews physicians more restrained, this is due to widespread reluctance to recommend drugs that affect the immune system, due to the small study of their effect on the immune system in the long term.
Price Tsitovir 3
Cost Tsitovir syrup for children 3 in Ukraine is 145 UAH. In Russia, the price of syrup is close to 270 rubles, Tsitovir-3 capsule It can be bought for 255-280 rubles.
Price counterparts in other forms of production varies greatly: for example, the price of tablets (6 pieces) Lavomax - 440 rubles, and 20 tablets Immunal cost 210-220 rubles.
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